thr77 login Options
thr77 login Options
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The antibody is from purified rabbit serum by affinity purification by using sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
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Overexpression of this gene continues to be observed in many tumors, which ends up in chromosome instability, and so could contribute to tumorigenesis. This protein was identified to affiliate with, and be associated with, the phosphorylation of NPAT protein (nuclear protein mapped into the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a vital part in selling mobile-cycle progression within the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode unique isoforms, are described. Two additional splice variants had been noted but comprehensive nucleotide sequence details isn't nonetheless accessible.
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Blocking peptides are peptides that bind specially into the target antibody and block antibody binding. These peptide typically has the epitope identified with the antibody.
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This guidebook outlines additional attainable optimization of cellular and immunoassay parameters to make sure the best possible success are...
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This guideline outlines even more possible optimization of cellular and immunoassay parameters to be certain the best possible benefits are...
Antibodies bound to the blocking peptide not bind on the epitope on the concentrate on protein. By comparing the staining in the blocked antibody compared to the antibody on your own, one can see which staining is distinct.
Target Details Cyclin E belongs to your really conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the mobile cycle. Cyclins function more info as regulators of CDK kinases. Unique cyclins show distinct expression and degradation designs which lead towards the temporal coordination of every mitotic function. Cyclin E types a posh with and features to be a regulatory subunit of CDK2, whose exercise is needed for cell cycle G1/S transition. This protein accumulates within the G1-S period boundary and is degraded as cells progress by means of S stage.
The measurement of protein phosphorylation is a useful tool for measuring the modulation of receptor activation by each antibodies...
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